Two approaches have characterised analysis of the postcolonial state in Africa. One emphasises the territorial integrity of the postcolonial state, with inherited colonial borders being viewed as sacrosanct and state-centred rights being given primacy. The other questions the sacrosanctity of colonial borders and seeks to promote the primacy of people-centred rights. The increasing frequency in recent years of quests for self-determination and secession in Africa poses an existential challenge to the postcolonial state on that continent. This Policy Note addresses this emerging trend.